Gas fermentation: cellular engineering possibilities and scale up

Gas fermentation: cellular engineering possibilities and scale up

Low carbon fuels and chemicals can be sourced from renewable materials such as biomass or from industrial and municipal waste streams. Gasification of these materials allows all of the carbon to become available for product generation, a clear advantage over partial biomass conversion into fermentable sugars. Gasification results into a synthesis stream (syngas) containing carbon monoxide (CO),...

Bioreactor Scale-up for Water-Gas Shift Reaction

A scale-up study has been performed with three different size reactors to establish the optimum operating conditions for the hydrogen production from synthesis gas by biological water-gas shift reaction using the photosynthetic bacterium Rhodosprilliunt rubrum. Optimum medium composition and operating conditions previously determined in a bench scale 1.25 L continuous stirred tank reactor (CSTR...

Biofuel production: an odyssey from metabolic engineering to fermentation scale-up

Metabolic engineering has developed microbial cell factories that can convert renewable carbon sources into biofuels. Current molecular biology tools can efficiently alter enzyme levels to redirect carbon fluxes toward biofuel production, but low product yield and titer in large bioreactors prevent the fulfillment of cheap biofuels. There are three major roadblocks preventing economical biofuel...

Production Scale Up of Nanofibers: A Review

An Engineering Scale-Up Approach using Multi-Objective Optimization

In science and engineering, researchers are often challenged with the need to replicate the innovative results obtained with an equipment of a given size in another equipment of a different dimension. In practice, this often involves passing from laboratory or prototype dimensions to industrial level. The process is known as scale-up and consists in ensuring that the values of the criteria that...